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KMID : 1007320090150020093
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Journal of the Korean Society of Menopause
2009 Volume.15 No. 2 p.93 ~ p.100
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Relationship Between Serum Homocysteine Concentration and Bone Mineral Density in Perimenopausal and Postmenopausal Korean Women
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Suh Heuy-Sun
Yang Kyn-Suk
Kim Kyoung-Kon
Lee Kyu-Rae
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Abstract
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Objectives: There is growing interest in the relationship between the serum homocysteine concentration and bone mineral density (BMD); however, few such studies have been published. Hence, the objective of this research was to determine the relationship between the serum homocysteine concentration and BMD in perimenopausal and postmenopausal women.
Methods: One hundred nine perimenopausal and postmenopausal women who attended the department of family medicine at a university hospital between August 2006 and January 2007 were recruited. The blood was sampled, the lumbar and femur neck BMD were measured, smoking habits were established, and the alcohol, caffeine, and milk consumption of the participants were determined. The participants were divided into three groups according to the BMD (osteoporosis, osteopenia, and normal), and the differences between the three groups were analyzed with ANOVA or Fisher’s exact test. Multiple regression analysis was used to analyze factors affecting serum homocysteine. Correlation analysis was performed to determine the relationship between the serum homocysteine concentration and BMD adjusted by factors affecting homocysteine in the multiple regression analysis results.
Results: With respect to BMD, the three groups exhibited some differences (P＜0.05) in terms of age and milk consumption, but the serum homocysteine level was not different between the three groups. The serum homocysteine level was individually associated (P＜0.05) with serum glucose, serum creatinine, HDL-cholesterol, and femur neck BMD. Although a correlation was established (?=?0.25, P=0.01) between the femur neck BMD and homocysteine concentration when adjusted for serum glucose, serum creatinine, and HDL- cholesterol, there was no such relationship present (?=0.027, P=0.786) between the lumber BMD and the homocysteine concentration.
Conclusion: An increased serum homocysteine concentration in perimenopausal and postmenopausal women is associated with the reduction in the femur neck BMD. Hence, the increase in the serum homocysteine level can be considered to be one of the risk factors for osteoporosis.
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KEYWORD
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Homocysteine, Bone mineral density, Osteoporosis, Osteopenia
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